In a Nov. 13 study in the journal PLOS ONE, University at
Buffalo biologists report that being severely overweight impaired the ability
of mice to detect sweets.
Compared with slimmer counterparts, the plump mice had fewer
taste cells that responded to sweet stimuli. What's more, the cells that did
respond to sweetness reacted relatively weakly.
The findings peel back a new layer of the mystery of how
obesity alters our relationship to food.
"Studies have shown that obesity can lead to
alterations in the brain, as well as the nerves that control the peripheral
taste system, but no one had ever looked at the cells on the tongue that make
contact with food," said lead scientist Kathryn Medler, PhD, UB associate
professor of biological sciences.
"What we see is that even at this level -- at the first
step in the taste pathway -- the taste receptor cells themselves are affected
by obesity," Medler said. "The obese mice have fewer taste cells that
respond to sweet stimuli, and they don't respond as well."
The research matters because taste plays an important role
in regulating appetite: what we eat, and how much we consume.
How an inability to detect sweetness might encourage weight
gain is unclear, but past research has shown that obese people yearn for sweet
and savory foods though they may not taste these flavors as well as thinner
people.
Medler said it's possible that trouble detecting sweetness
may lead obese mice to eat more than their leaner counterparts to get the same
payoff.
Learning more about the connection between taste, appetite
and obesity is important, she said, because it could lead to new methods for
encouraging healthy eating.
"If we understand how these taste cells are affected
and how we can get these cells back to normal, it could lead to new
treatments," Medler said. "These cells are out on your tongue and are
more accessible than cells in other parts of your body, like your brain."
The new PLOS ONE study compared 25 normal mice to 25 of
their littermates who were fed a high-fat diet and became obese.
To measure the animals' response to different tastes, the
research team looked at a process called calcium signaling. When cells
"recognize" a certain taste, there is a temporary increase in the
calcium levels inside the cells, and the scientists measured this change.
The results: Taste cells from the obese mice responded more
weakly not only to sweetness but, surprisingly, to bitterness as well. Taste
cells from both groups of animals reacted similarly to umami, a flavor
associated with savory and meaty foods.
Medler's co-authors on the study were former UB graduate
student Amanda Maliphol and former UB undergraduate Deborah Garth.